Joining them, former Representative Joe Kennedy III of Massachusetts, the health secretary’s nephew, took to X Friday, calling his uncle “a threat to the health and wellbeing of every American,” who has chosen to “dismiss science, mislead the public, sideline experts and sow confusion.”

“None of us will be spared the pain he is inflicting. It doesn’t matter how rich or powerful you are or what state you live in—the heartbreak of watching a loved one fall ill knows no borders,” Kennedy wrote. “The challenges before us—from disease outbreaks to mental health crises—demand moral clarity, scientific expertise, and leadership rooted in fact. Those values are not present in the Secretary’s office. He must resign.”

This is not the first time members of the Kennedy family have condemned RFK Jr.—with his long-shot presidential campaign and, later, his endorsement of Trump both drawing public objections from his family. During his confirmation process, his cousin Caroline Kennedy urged the Senate to reject his nomination, writing that the American public “deserve[s] better than Bobby Kennedy.” During Thursday’s hearing, John F. Kennedy’s grandson Jack Schlossberg (RFK Jr.’s first cousin once removed) posted on X, “RFK LOSER is choking so badly LIVE.”